(DOWNLOAD) "Butyrylcholinesterase Activity, Cardiovascular Risk Factors, And Mortality in Middle-Aged and Elderly Men and Women in Jerusalem (Lipids, Lipoproteins, And Cardiovascular Risk Factors)" by Clinical Chemistry # Book PDF Kindle ePub Free
eBook details
- Title: Butyrylcholinesterase Activity, Cardiovascular Risk Factors, And Mortality in Middle-Aged and Elderly Men and Women in Jerusalem (Lipids, Lipoproteins, And Cardiovascular Risk Factors)
- Author : Clinical Chemistry
- Release Date : January 01, 2006
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 229 KB
Description
Although butyrylcholinesterase (BuChE) (1) was discovered more than 70 years ago (1), its physiologic importance is poorly understood. This enzyme has low affinity for acetylcholine and a wide range of substrates and exists in a soluble form in both the brain and plasma. In the brain, BuChE is also found in a hydrophobic form, attached to cell membranes (2). Many studies on BuChE have been reported, as summarized in 2 reviews (2, 3). Most of the studies were conducted in vitro or in animal models. Of the small proportion undertaken in humans, very few were rigorous epidemiologic studies. Interest in BuChE has been growing because of its possible role in Alzheimer disease and the introduction of anticholinesterase treatments for this disorder (2). Alzheimer disease itself was reported to be associated with cardiovascular risk factors such as hypertension and increased serum cholesterol (4). Previous reports suggested that BuChE enzymatic activity was higher in patients who had hypertension, hyperlipidemia, and high body weight and lower in patients who had suffered acute myocardial infarction or undergone treatment with beta blockers (5-7).